海峡生命科学前沿论坛第135讲(2019.6.27)-Multiscale cell fate through lens of single cells


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时??????? ?间:2019年6月27日上午9:00-1000

地??????? ?点:研院林学中心会议室301 ??

主办单位海峡联合研究院园艺中心

报? ?告? ?Qing ?Nie Departments ?of Developmental & Cell Biology and Mathematics NSF-Simons Center for ?Multiscale Cell Fate ResearchUniversity ?of California, Irvine

报告题目Multiscale ?cell fate through lens of single cells

Abstract:

Cells ?make fate decisions in response to dynamic environmental and pathological ?stimuli as well as cell-to-cell communications. ?Recent technological ?breakthroughs have enabled to gather data in previously unthinkable quantities ?at single cell level, starting to suggest that cell fate decision is much more ?complex, dynamic, and stochastic than previously recognized. Multiscale ?interactions, sometimes through cell-cell communications, play a critical role ?in cell decision-making. Dissecting cellular dynamics emerging from molecular ?and genomic scale in single-cell demands novel computational tools and ?multiscale models. In this talk, through multiple biological examples we will ?present our recent works to use single-cell RNA-seq data and spatial imaging ?data to uncover new insights in development, regeneration, and cancers. We will ?also present several new computational tools and mathematical modeling methods ?that are required to study the complex and dynamic cell fate process through the ?lens of single cells.


Short ?Bio

Dr. ?Qing Nie is a Chancellor’s Professor of Mathematics, Developmental and Cell ?Biology, and Biomedical Engineering at University of California, Irvine. Dr. Nie ?is the director of the new NSF-Simons ?Center for Multiscale Cell Fate Research?jointly ?funded by NSF and the Simons Foundation – one of the four national centers on ?mathematics of complex biological systems. In research, he uses systems biology ?and data-driven methods to study complex biological systems with focuses on ?single-cell analysis, multiscale modeling, cellular plasticity, stem cells, ?embryonic development, and their applications to diseases. Dr. Nie has published ?more than 140 research articles and served in many NIH and NSF review panels, ?maintaining a well-funded interdisciplinary research program. In training, Dr. ?Nie has supervised more than 40 postdoctoral fellows and PhD students, with ?majority of them working in academic institutions. Dr. Nie is a fellow of the ?America ?Association for the Advancement of Science?and ?a fellow of American ?Physical Society. ?


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